{"product_id":"ipamorelin","title":"Ipamorelin","description":"\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eIpamorelin | Aib-His-D-2-Nal-D-Phe-Lys-NH₂ | Selective GHS-R1a Agonist | Research Peptide\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Aib-His-D-2-Nal-D-Phe-Lys-NH₂ \u003cstrong\u003eClassification:\u003c\/strong\u003e Synthetic pentapeptide — selective growth hormone secretagogue receptor 1a (GHS-R1a) agonist \/ GHRP \u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₃₈H₄₉N₉O₅ \u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 711.85 g\/mol \u003cstrong\u003eKey Structural Features:\u003c\/strong\u003e α-aminoisobutyric acid (Aib) at position 1; D-2-naphthylalanine (D-2-Nal) at position 3; D-phenylalanine (D-Phe) at position 4 \u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC verified) \u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder \u003cstrong\u003eAvailable Sizes:\u003c\/strong\u003e 5mg | 10mg \u003cstrong\u003eStorage:\u003c\/strong\u003e –20°C, away from light and moisture \u003cstrong\u003eCAS Number:\u003c\/strong\u003e 170851-70-4\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eWhat Is Ipamorelin?\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eIpamorelin is a synthetic pentapeptide growth hormone-releasing peptide (GHRP) and selective agonist of the ghrelin receptor (GHS-R1a), originally developed by Novo Nordisk in Denmark and first characterised in a landmark 1998 paper in the European Journal of Endocrinology by Raun and colleagues. It was derived from GHRP-1 through a systematic chemistry programme that identified active analogues lacking the central Ala-Trp dipeptide of the parent compound, ultimately yielding ipamorelin as the most pharmacologically refined member of its series.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eIpamorelin's significance in the research peptide landscape rests on a single, defining characteristic: it is the first growth hormone-releasing peptide receptor agonist to demonstrate a selectivity for GH release comparable to that of endogenous GHRH itself. All earlier GHRPs — including GHRP-2 and GHRP-6 — stimulated GH release but also produced dose-dependent elevations in ACTH and cortisol through activation of broader stress-response signalling pathways. Ipamorelin does not. In the foundational Novo Nordisk pharmacology studies, ipamorelin failed to elevate ACTH or cortisol at doses more than 200-fold above its ED50 for GH release — a specificity profile that had not previously been achieved with any GHRP receptor agonist and that fundamentally changed the landscape of GH secretagogue research.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eStructurally, ipamorelin incorporates three key non-natural amino acid features that underpin its selectivity and metabolic stability. The α-aminoisobutyric acid (Aib) residue at position 1 confers resistance to N-terminal peptidase cleavage. The D-2-naphthylalanine (D-2-Nal) at position 3 — a bulky, non-natural amino acid — provides critical receptor binding contributions and contributes to selectivity. The D-phenylalanine (D-Phe) at position 4 further stabilises the receptor-bound conformation. Together, these modifications produce a compound with substantially lower systemic plasma clearance than GHRP-6 — approximately five-fold lower — and moderate resistance to metabolic degradation, resulting in a more sustained and reproducible GH secretory response.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eIpamorelin stimulates pulsatile GH secretion from anterior pituitary somatotrophs by acting at the ghrelin receptor (GHS-R1a) — a distinct and mechanistically complementary pathway to the GHRH receptor pathway through which CJC-1295 No DAC and tesamorelin operate. This mechanistic distinction is the basis of the well-established synergistic relationship between ipamorelin and GHRH analogues in GH secretion research.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eOur ipamorelin is synthesised under rigorous quality-controlled manufacturing conditions, verified to a purity of greater than 99% by HPLC and Mass Spectrometry, and supplied as a lyophilised (freeze-dried) powder for maximum stability.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eResearch Background \u0026amp; Scientific Interest\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eIpamorelin has accumulated a rich and diverse body of preclinical research since its characterisation in 1998, spanning GH secretagogue pharmacology, metabolic biology, bone mineral density, gastrointestinal motility, and body composition research. Its defining selectivity profile has made it the reference compound of choice for ghrelin receptor agonism research where hormonal specificity is a priority experimental requirement.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGHS-R1a Receptor Pharmacology \u0026amp; Selectivity\u003c\/strong\u003e Ipamorelin's receptor pharmacology was comprehensively characterised in the original Novo Nordisk studies. In vitro, ipamorelin released GH from primary rat pituitary cells with a potency and efficacy closely comparable to GHRP-6 — achieving an EC50 of 1.3 ± 0.4 nmol\/L and an Emax of 85 ± 5% relative to GHRP-6's 100% reference maximum. In vivo, in conscious swine — a model with GH axis pharmacology closely reflective of human GH secretion — ipamorelin produced an ED50 of 2.3 ± 0.03 nmol\/kg and an Emax of 65 ± 0.2 ng GH\/mL plasma, comparable to GHRP-6 (ED50 3.9 ± 1.4 nmol\/kg, Emax 74 ± 7 ng\/mL) but with substantially superior selectivity. Critically, pharmacological profiling using both GHRP receptor antagonists and GHRH antagonists confirmed that ipamorelin stimulates GH release exclusively via the GHRP\/ghrelin receptor pathway — the same receptor used by GHRP-2 and GHRP-6 — rather than through the GHRH receptor. This orthogonal mechanism is the mechanistic basis of the synergistic GH release observed when ipamorelin is combined with GHRH analogues such as CJC-1295 No DAC.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eHormonal Selectivity: No ACTH, Cortisol, Prolactin or Gonadotropin Elevation\u003c\/strong\u003e The most scientifically significant finding in the ipamorelin pharmacology literature is its hormonal selectivity profile. In the definitive swine selectivity study, none of the GH secretagogues tested — including ipamorelin, GHRP-6, and GHRP-2 — affected FSH, LH, prolactin, or TSH levels. However, administration of both GHRP-6 and GHRP-2 produced significant elevations in plasma ACTH and cortisol. Ipamorelin produced no significant elevation in ACTH or cortisol at any dose tested — including doses exceeding 200-fold the GH-releasing ED50. This was described by the original authors as \"very surprising\" and represented a categorically different selectivity profile from all previously characterised GHRP receptor agonists. The practical research implication is substantial: studies using ipamorelin to investigate GH\/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis — a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003ePulsatile GH Secretion \u0026amp; IGF-1 Axis Research\u003c\/strong\u003e Like CJC-1295 No DAC, ipamorelin stimulates pulsatile rather than continuous GH secretion. Its half-life of approximately two hours in rodent models — longer than GHRP-6 due to its approximately five-fold lower systemic plasma clearance — produces GH pulses of meaningful duration while preserving the inter-pulse intervals that allow natural somatostatin feedback to operate. Elevated GH secretion drives downstream IGF-1 production, mediated primarily through hepatic GH receptor signalling, and the GH\/IGF-1 axis effects of ipamorelin — including anabolic signalling in skeletal muscle, lipolytic activity in adipose tissue, and effects on bone metabolism — have been studied in multiple preclinical models.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBone Mineral Density Research\u003c\/strong\u003e Ipamorelin has been studied in models of bone metabolism, with preclinical data demonstrating increases in bone mineral content (BMC) in treated female rats as measured by dual-energy X-ray absorptiometry (DXA) in vivo. Comparative studies examining ipamorelin and GHRP-6 both demonstrated BMC increases, consistent with the known role of the GH\/IGF-1 axis in bone formation, periosteal expansion, and endochondral ossification. These findings have positioned ipamorelin as a tool of interest in preclinical osteoporosis research and models of GH deficiency-associated bone loss.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eGastrointestinal Motility Research\u003c\/strong\u003e The GHS-R1a receptor is expressed not only in the pituitary and hypothalamus but throughout the gastrointestinal tract — reflecting the physiological role of ghrelin as a gut-derived hormone regulating gastric motility and appetite. Ipamorelin has been studied in preclinical models of gastrointestinal dysfunction, including postoperative ileus (POI) — a clinically important condition characterised by delayed gastric emptying following abdominal surgery. Studies by Greenwood-Van Meerveld and colleagues using rodent POI models demonstrated that ipamorelin produced dose-dependent improvements in gastric emptying and reversal of POI-induced delayed gastrointestinal transit, with effects mediated through GHS-R1a expressed in gastrointestinal smooth muscle and enteric nervous system tissue. These findings have expanded ipamorelin's research relevance into gastrointestinal biology beyond its primary GH secretagogue profile.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eBody Composition \u0026amp; Metabolic Research\u003c\/strong\u003e The downstream metabolic effects of ipamorelin-stimulated GH\/IGF-1 axis activation — including GH-mediated lipolysis in adipose tissue, IGF-1-mediated skeletal muscle protein synthesis, and nitrogen retention — have made ipamorelin a useful tool in preclinical body composition research. Studies have examined ipamorelin in models of lean mass accretion, visceral fat reduction, and metabolic syndrome, with findings consistent with the broader GH\/IGF-1 axis literature. Its hormonal selectivity — specifically the absence of cortisol elevation — is a meaningful research advantage in these models, as elevated cortisol has well-documented catabolic effects on muscle tissue that would otherwise confound body composition outcomes.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCombination Research: Ipamorelin + CJC-1295 No DAC (GHRH + GHRP Synergy)\u003c\/strong\u003e One of the most important and widely replicated findings in GH secretagogue research is the synergistic relationship between GHRH-axis peptides and GHRP-class peptides in stimulating GH release. When a GHRH analogue (such as CJC-1295 No DAC) and a GHRP (such as ipamorelin) are administered together, the combined GH release substantially exceeds the sum of the individual responses — a finding consistent with the well-established physiological synergism between the hypothalamic GHRH and ghrelin systems. This occurs because the two compounds act through distinct and mechanistically independent receptors (GHRH-R and GHS-R1a respectively), and their downstream signalling cascades converge synergistically at the level of pituitary somatotroph GH secretion. This combination paradigm — CJC-1295 No DAC paired with ipamorelin — has become one of the most commonly used experimental protocols in preclinical GH-axis research, and both compounds are available in our catalogue to support this research design.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eIpamorelin vs. GHRP-2 and GHRP-6: Selectivity Comparison\u003c\/h3\u003e\n\u003cdiv class=\"overflow-x-auto w-full px-2 mb-6\"\u003e\n\u003ctable class=\"min-w-full border-collapse text-sm leading-[1.7] whitespace-normal\"\u003e\n\u003cthead class=\"text-left\"\u003e\n\u003ctr\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eParameter\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eIpamorelin\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eGHRP-6\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eGHRP-2\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eGH release potency (swine)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eED50 ~2.3 nmol\/kg\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eED50 ~3.9 nmol\/kg\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eED50 ~0.6 nmol\/kg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eGH release efficacy (swine)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eEmax ~65 ng\/mL\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eEmax ~74 ng\/mL\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eEmax ~56 ng\/mL\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eACTH\/cortisol elevation\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eNone (even at 200× ED50)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSignificant\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSignificant\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eProlactin\/gonadotropin effects\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eNone\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eNone\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eNone\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003ePlasma clearance vs GHRP-6\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e~5× lower\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eReference\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eLower than GHRP-6\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAppetite \/ gastric effects\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eMild (GHS-R1a mediated)\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSignificant\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eModerate\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThis table illustrates why ipamorelin has become the preferred GHRP for researchers where hormonal specificity and clean pharmacology are experimental priorities — delivering comparable GH release potency to GHRP-6 while eliminating the ACTH and cortisol confounders that complicate interpretation of results with the older compounds.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eProduct Specifications\u003c\/h3\u003e\n\u003cdiv class=\"overflow-x-auto w-full px-2 mb-6\"\u003e\n\u003ctable class=\"min-w-full border-collapse text-sm leading-[1.7] whitespace-normal\"\u003e\n\u003cthead class=\"text-left\"\u003e\n\u003ctr\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eSpecification\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eDetail\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003ePeptide\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eIpamorelin\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSequence\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAib-His-D-2-Nal-D-Phe-Lys-NH₂\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eClassification\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSelective GHS-R1a agonist \/ GHRP\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eMolecular Formula\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eC₃₈H₄₉N₉O₅\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e711.85 g\/mol\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003ePurity\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e\u0026gt;99% (HPLC \u0026amp; MS verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eForm\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eLyophilised powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eVial Sizes\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e5mg, 10mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAppearance\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eWhite to off-white powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSolubility\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSoluble in sterile bacteriostatic water or PBS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eStorage\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e–20°C, keep away from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e24 months when stored correctly (lyophilised)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e170851-70-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eQuality \u0026amp; Purity Assurance\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eEvery batch of our ipamorelin undergoes a comprehensive multi-stage quality control process before release. Our assurance pipeline includes:\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eHPLC Analysis\u003c\/strong\u003e — confirms peptide purity exceeding 99%\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eMass Spectrometry (MS)\u003c\/strong\u003e — verifies molecular identity, non-natural amino acid incorporation (Aib, D-2-Nal, D-Phe), and full pentapeptide sequence accuracy\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eEndotoxin Testing\u003c\/strong\u003e — ensures the product is free from bacterial endotoxins\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eCertificate of Analysis (CoA)\u003c\/strong\u003e — available for every batch upon request\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThe three non-natural amino acids in ipamorelin — Aib, D-2-Nal, and D-Phe — are analytically critical features that distinguish it from related GHRPs. Our MS verification process explicitly confirms their incorporation to ensure the correct compound is delivered with research-grade accuracy and batch-to-batch consistency.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eHandling \u0026amp; Reconstitution (Research Use)\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eIpamorelin lyophilised powder should be reconstituted using sterile bacteriostatic water. Inject slowly against the side of the vial and swirl gently — do not vortex. Once reconstituted, aliquot and store at 2–8°C. Use within 28–30 days of reconstitution. The compound exhibits moderate resistance to metabolic degradation in solution, but repeated freeze-thaw cycles should nonetheless be avoided to maintain research-grade integrity.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAll handling should comply with standard laboratory safety protocols and applicable institutional or regulatory guidelines.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eIpamorelin Within the Research Peptide Catalogue\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eIpamorelin occupies the ghrelin receptor agonist \/ GHRP position within our GH-axis research toolkit — mechanistically complementary to, and synergistic with, the GHRH-axis compounds CJC-1295 No DAC and tesamorelin, and distinct from the direct GH replacement approach of rhGH.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eWithin the broader catalogue, ipamorelin's GHS-R1a-mediated GH\/IGF-1 axis activity is mechanistically distinct from the tissue-repair focus of BPC-157 and TB-500, the genomic and matrix biology of GHK-Cu, the mitochondrial metabolic signalling of MOTS-c, the systemic triple hormonal agonism of retatrutide, the intracellular NAD+ axis of 5-Amino-1MQ, and the neuropeptide biology of Selank. Our full GH axis research toolkit now comprises three distinct mechanistic entry points: ghrelin receptor agonism (ipamorelin), GHRH receptor agonism (CJC-1295 No DAC, tesamorelin), and direct GH replacement (rhGH) — providing researchers with the tools to study GH biology from upstream secretagogue stimulation through to receptor-level replacement.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAll peptides are manufactured to the same \u0026gt;99% purity standard and supported by batch-specific Certificates of Analysis.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003eImportant Notice\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003eThis product is intended strictly for in vitro research and laboratory use only. Ipamorelin is not approved for human or veterinary use by the FDA, EMA, or any other regulatory authority. It is not a drug, supplement, or food product. This product must not be administered to humans or animals. By purchasing this product, the buyer confirms they are a qualified researcher and will use the compound solely for lawful scientific research purposes.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"NEXYRALAB","offers":[{"title":"5mg","offer_id":59643105542478,"sku":null,"price":15.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":59643105575246,"sku":null,"price":29.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1035\/3351\/0990\/files\/hf_20260512_161949_79447409-1a83-4bd4-8386-ce029588bbff.png?v=1779451031","url":"https:\/\/nexyralab.com\/products\/ipamorelin","provider":"Nexyralab.com","version":"1.0","type":"link"}